个人简介
耿洁，硕士生导师，中山大学博士、清华大学博士后。主持国家级课题1项，省部级及校级课题3项。获北京市科学技术奖自然科学奖一等奖（机械力受体PIEZO的结构功能机制）。目前主要从事天然产物治疗免疫性疾病的作用机制研究，同时深耕离子通道结构与功能研究。已建立天然产物靶点筛选、动物模型构建、分子生物学、细胞生物学、生物化学及结构生物学等完备的研究体系与技术平台。相关研究成果以第一作者或通讯作者发表于Neuron（2016、2020）、pharmaceuticals（2025）等。
研究方向
1. 天然产物治疗免疫性疾病的作用机制
2. 离子通道结构与功能
主要成果
1. Geng jie*; Liu Wenhao*; Zhou Heng*; Zhang Tingxin*; Wang Li*; Zhang Mingmin; Li Yiran; Shen Bo; Li Xueming#; Xiao Bailong# . A Plug-and-Latch Mechanism for Gating the Mechanosensitive Piezo Channel, Neuron, 2020, 106(3): 438-451
2. Xuanhe Liu*; Dan Zhang*; Yuting Xie; Mengdan Wang; Xiaochun Chen; Weijie Yu; Yuming Ma; Jia Zeng; Qixuan Long; Guangrui Huang; Jie Geng#; Anlong Xu#; Drug Pair of Astragali Radix-Ligustri Lucidi Fructus Alleviates Acute Kidney Injury in Mice Induced by Ischemia-Reperfusion Through Inhibiting Ferroptosis, Pharmaceuticals (Basel). 2025, 18(6):789
3. Zhao Qiancheng*; Zhou Heng*; Chi Shaopeng*; Wang Yanfeng*; Wang Jianhua; Geng Jie; Wu Kun; Liu Wenhao; Tingxin Zhang; Dong Mengqiu; Wang Jiawei; Li Xueming; Xiao Bailong ; Structure and Mechanogating Mechanism of the Piezo1 Channel, Nature, 2018, 554(7693): 487-492
4. Zhao Qiancheng*; Wu Kun*; Geng Jie;* Chi Shaopeng*; Wang Yanfeng; Zhi Peng; Zhang Mingmin; Xiao Bailong# ; Ion Permeation and Mechanotransduction Mechanisms of Mechanosensitive Piezo Channels, Neuron, 2016, 89(6): 1248-1263
5. Yujiao Huang*; Jie Geng*; Mengdan Wang; Wenbin Liu; Haikun Hu; Wei Shi; Mei Li; Guiyang Huo; Guangrui Huang#; Anlong Xu# . A simple protocol to establish a conditionally immortalized mouse podocyte cell line, Scientific Reports, 2024, 14(11591)
6. Liu Wenbin*; Huang Guangrui*; Liu Baoli*; Hu Haikun*; Geng Jie; Rui Hong-liang; Gao Chang; Huang Yujiao; Huo Guiyang; Mao Jiarong; Lu Chuanjian; Xu Anlong#. Single cell landscape of parietal epithelial cells in healthy and diseased states, kidney international, 2023, 104(1): 108-123